The work in our lab is focused on identifying the molecular networks that are essential for early heart development and how alterations in these networks lead to congenital heart disease. For these studies, we use a highly integrated approach that incorporates developmental, genetic, proteomic, biochemical and molecular based studies in Xenopus, mouse and stem cells.
Recent advances and projects of interest in the Conlon lab include studies that define the cellular and molecular events that lead to cardiac septation, those that explore cardiac interaction networks as determinants of transcriptional specificity, the mechanism and function of cardiac transcriptional repression networks, and the regulatory networks of cardiac morphogenesis.
C. Wilczweski, 2018, PNAS
This b-mode video displays a novel technique pioneered by a Conlon Lab graduate student: in-utero Doppler echocardiography of an e10.5 mouse embryo